Contribution of Resident Memory CD8+ T Cells to Protective Immunity against Respiratory Syncytial Virus and Their Impact on Vaccine Design

Worldwide, human respiratory syncytial virus (RSV) is the most common etiological agent for acute lower respiratory tract infections (ALRI).RSV-ALRI is the major cause of hospital admissions in young children, bilstein shocks jeep xj and it can cause in-hospital deaths in children younger than six months old.Therefore, RSV remains one of the pathog

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Ribosome biogenesis disruption mediated chromatin structure changes revealed by SRAtac, a customizable end to end analysis pipeline for ATAC-seq

Abstract The nucleolus is a large nuclear body that serves as the primary site for ribosome biogenesis.Recent studies have suggested that it also plays an important role in organizing chromatin architecture.However, to establish a causal relationship between nucleolar ribosome assembly and chromatin architecture, genetic tools are required to disru

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